Drugs & Vitamins

Warfarin injection Active Ingredients: Warfarin injection Representative Names: Coumadin Injection Available Product Images: What is warfarin injection? What should I tell my health care provider before I take this medicine? How should I take this medicine? What if I miss a dose? What drug(s) may interact with warfarin? What side effects might I notice from taking warfarin? What should I watch for while taking warfarin? Where can I keep my medicine? What is warfarin injection? (Back to top) WARFARIN (Coumadin®) is an anticoagulant. Warfarin helps to treat or prevent clots in the veins, arteries, lungs, or heart. Warfarin stops clots from forming or getting bigger, and lets the body naturally dissolve the clots. Sometimes warfarin is called a blood thinner because you may bleed more easily while taking it; however, warfarin does not actually thin the blood. Generic warfarin injection is available. What should I tell my health care provider before I take this medicine? (Back to top) They need to know if you have any of these conditions: •If you frequently drink alcohol-containing beverage •blood disease, bleeding disorders, hemorrhage, hemophilia or aneurysm •bowel disease, diverticulitis, or ulcers •diabetes •heart valve infection •high blood pressure •kidney disease •liver disease •protein or vitamin deficiency •psychosis •recent surgery •thyroid problems •an unusual or allergic reaction to warfarin, other medicines, foods, dyes, or preservatives •pregnant or trying to get pregnant •breast-feeding How should I take this medicine? (Back to top) Warfarin injection is given by infusion into a vein. You will be given warfarin injection by a trained health care professional. What if I miss a dose? (Back to top) This does not apply. What drug(s) may interact with warfarin? (Back to top) Warfarin interacts with many other medicines; some are listed below: •acetaminophen •agents that dissolve blood clots •agents that lower cholesterol •alcohol •allopurinol •amiodarone •antibiotics or medicines for treating bacterial, fungal, or viral infections •antiinflammatory drugs, NSAIDs, such as ibuprofen •aprepitant •aspirin •azathioprine •barbiturate medicines for inducing sleep or treating seizures •bosentan •cimetidine •cranberry juice •cyclosporine •disulfiram •female hormones, including contraceptive or birth control pills •fish oil (omega-3 fatty acids) supplements •herbal products such as danshen, garlic, ginkgo, ginseng, green tea, or kava kava •influenza virus vaccine •male hormones •medicines for some types of cancer •certain medicines for heart rhythm problems •certain medicines for high blood pressure •quinidine, quinine •seizure or epilepsy medicine such as carbamazepine, phenytoin, and valproic acid •thyroid medicine •testolactone •tolterodine •vitamin K (including foods, vitamins, and dietary supplements that contain vitamin K) Tell your prescriber or health care professional about all other medicines that you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines. What side effects might I notice from taking warfarin? (Back to top) Side effects that you should report to your prescriber or health care professional as soon as possible: •signs and symptoms of bleeding such as bloody or black, tarry stools, red or dark-brown urine, spitting up blood or brown material that looks like coffee grounds, red spots on the skin, unusual bruising or bleeding from the eye, gums, or nose •back or stomach pain •chest pain; fast or irregular heartbeat (palpitations) •difficulty breathing or talking, wheezing •fever or chills •heavy menstrual bleeding •nausea, vomiting •painful, blue, or purple toes •skin rash, itching or skin damage •unusual swelling or sudden weight gain •unusual tiredness or weakness •yellowing of skin or eyes Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome): •diarrhea •loss of appetite •unusual hair loss What should I watch for while taking warfarin? (Back to top) Visit your prescriber or health care professional for regular checks on your progress. You will need to have your blood checked regularly to make sure you are getting the right dose of warfarin. The blood test that is used to monitor warfarin therapy is called the protime (PT) or INR. Your prescriber or health care professional will check your PT or INR and decide whether or not your dose of warfarin needs to be changed. When you first start warfarin, these tests are done frequently. Once the correct dose is determined and you take your medication properly, these tests can be done less often. While you are taking warfarin, carry an identification card with your name, the name and dose of medicine(s) being used, and the name and phone number of your prescriber or health care professional or person to contact in an emergency. You should discuss your diet with your prescriber or health care professional. Many foods and some dietary or vitamin supplements contain high amounts of vitamin K, which can interfere with the effect of warfarin. While taking warfarin, try to keep your dietary intake of vitamin K consistant. Foods that have moderate to high amounts of vitamin K include brussel sprouts, kale, green tea, asparagus, avocado, broccoli, cabbage, cauliflower, collard greens, liver, soybean oil, soybeans, certain beans, mustard greens, peas (blackeyed peas, split peas, chick peas), turnip greens, parsley, green onions, spinach, and lettuce. Warfarin can cause birth defects or other problems in an unborn child. Women of childbearing age should use effective contraception while receiving warfarin therapy. If a woman becomes pregnant while taking warfarin, she should discuss the potential risks and her options with her health care professional. Do not change brands of warfarin without talking to your prescriber or health care professional. Also, always check the color of your medicine when you get a new prescription. If you notice a change in the color of your warfarin tablet, check with your pharmacist or health care professional to make sure you received the correct medicine. Alcohol can affect the way warfarin works. Ask your prescriber or health care professional how much, if any, alcohol you may consume. Do not take any over-the-counter medicines without first talking to your prescriber or health care professional. Do not take any aspirin or aspirin-containing products, ibuprofen (Motrin®, Advil®, or Nuprin®) naprosyn (Aleve®), ketoprofen (Orudis-KT®) or other medicines known as nonsteroidal anti-inflammatory agents without talking to your prescriber or health care professional first. Be careful to avoid sports and activities that might cause injury while you are using warfarin. Severe falls or injuries can cause unseen bleeding. Be careful when using sharp tools or knives. Consider using an electric razor. Take special care brushing or flossing your teeth. Report any injuries, bruising, or red spots on the skin to your prescriber or health care professional. If you have an illness that causes vomiting, diarrhea, or fever for more than a few days, contact your doctor. Also check with your doctor if you are unable to eat for several days. These problems can change the effect of warfarin. Even after you stop taking warfarin, it takes several days before your body recovers its normal ability to clot blood. Ask your prescriber or health care professional how long you need to be cautious. If you are going to have surgery or dental work, tell your prescriber or health care professional that you have been taking warfarin. Where can I keep my medicine? (Back to top) You will receive warfarin injection in a hospital or clinic setting and will not take this medicine at home. Last Updated:12/26/2006 CLINICAL PHARMACOLOGY© GOLD STANDARD MULTIMEDIA INC, ALL RIGHTS RESERVED

Note: The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist, or other healthcare professional. It should not be construed to indicate that the use of the product is safe, appropriate, or effective for you. Consult your healthcare professional before taking the product.